Ge-132投与により臨床にもtow-color flow cytometryで観察した免疫学的評価でも改善を認めた慢性関節リウマチ症例

抄録

Ge-132, 1, 500mg per day, was administered to 47 y-o house wife who suffered from rheumatoid arthritis associated with Sjögren's syndrome and microcytic hypochromic anemia since 1983. Her clinical stage of rheumatoid arthritis was Stage II and class was 1. Polyarth-ralgia and joint swelling were getting worse even though she was administered both non-steroidal antiinflammatory drug and small dose of prednisolone. Treatment with Ge-132 brought her in a remission state of rheumatoid arthritis and MCV and MCH as well as Hb were improved within 5 months. Two-color flow cytometry of peripheral lymphocytes demonstrated an increase of lymphocyte, CD3^-, CD21⁺ (B cell), CD3⁺, CD21^- (T cell), CD4^-, CD8⁺ (suppressor T cell), CD4⁺, CD8^- (helper T cell), CD16⁺, DR^- (NK cell) and all of double negative cells such as CD3^-, CD21^- cell, CD4^-, C8^- cell, and CD16^-, DR^-cell, parallel to clinical status.
These data surely indicated that Ge-132 is effective to this patient.