抄録
The first aim of this study is to determine the relative effects on intragastric pH of administration of famotidine and pirenzeprne. The second aim is to determine the rate of bacterial growth in gastric juice at various pH values in relation to the addition of famotidine and pirenzepine.
A group of fourteen ventilated patients, six of whom were treated with famotidine (Group F) and eight of whom with pirenzeprne (Group P), were intubated with nasogastric catheter. Gastric aspirate specimens were colleccted every morning to check pH and were cultured quantitatively and identified on admission and on daily for 1, 3, 5, 7 days.
One hundred twenty-two measurements of gastric pH were carried out. Median pH values for the group F was significantly higher than the group P (mean pH F/P=5.63±1.91/2.72±1.51, p<0.01). Furthermore, the rate of gastric pH≥4 in Group F was significantly higer than that in Group P (F/P=81%/13%, p<0.01). Seventy gastric juice cultures revealed 43 (61%) positive cultures. Furthermore, the rate of positive culture in Group F was significantly higher than that in Group P (F/P=83%/43%, p<0.05). No patients showed, clinically macroscopically, upper GI bleeding in this study.
In conclusion, pirenzepine is more useful than famotidine because pirenzepine provides adequate protection against stress upper GI bleeding with less overgrowth of bacteria in the stomach than famotidine.
