炎症
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
ヒト白血球からのヒスタミン放出に及ぼすベンジルイソキノリン型化合物の効果
坂下 広嗣礒野 恵美子井上 肇石田 寛友村越 善衛
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1993 年 13 巻 5 号 p. 501-503

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The antiinflammatory and antiallergic effects of CE were evaluated by measuring antigen-induced histamine release from leukocytes and the following results were obtained. (1) CE inhibited his-tamine release from leukocytes at dose dependent manner. (2) Homoaromoline, cepharanoline and aromoline also inhibited antigen-induced histamine release stronger than CE and isotetrandrine sup-pressed histamine release but its suppression was not dose dependent. (3) Cepharanthin, berbamine and cycleanine did not inhibit histamine release from leukocytes with dose dependency.
These results suggest that the main sources of anti-allergic effect of CE were in homoaromoline, aromoline and cepharanoline.
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