実質臓器悪性腫瘍に対する光化学治療

抄録

In experiment in vitro, PDT(HpD-Argon dye laser) was performed for HC-4 liver tumor cells (cultured human liver tumor) in the medium with HpD. Remarkable cytocydal effect was obtained by PDT with an efficient difference.
In experiment in vivo, using the HC-4 liver tumor bearing nude mouse, severe tumor necrosis was observed without damage of surrounding tissue and no tumor growth was resulted.
in experiment of PDT for the normal liver tissue, spherical tissue necrosis of about 10mm in diameter was observed after PDT following 60 minutes after HpD administration.
As a result, clinical application of PDT for malignant tumor of the parenchymal organs would be supported.