We demonstrated last year that HpD accumulated large amounts in the both of ascites and ascites tumours of Balb/c ascites mouse and had cytocidal effects against the tumour cells. Then, we attempt to perform PDT using hematoporphyrin esters (HpE) to the pleural effusion type lung carcinoma to control the effusion, But the patient died of pulmonary failure, so we had to abandan to perform PDT, However we took specimens from the effusion, the lung carcinoma and the other organs. We compared the accumulation of HpE to the pleural effusion from the other organs. HpE accumulated in pleural effusion 3 times greater than in normal lung tissues at 48 hours after HpE injection. The result indicates that it may be possible to control malignant effusion of clinical case by PDT.
