悪性脳腫瘍に対する穿刺法による PDT の問題点

抄録

A stereo tactically applied PDT was performed in the 64 year old male with metastatic brain tumor from lung Carcinoma.
48 hours of ter 3mg/kg HPD administrations, optical fiber was inserted into four regions to photoradiate the whole tumor for the total dose of 1176 joules (250mw×20mins×4) using Kornai stereotactic apparatus.
The patient died 28 days of ter PDT because of other disease.
Autopsy was done and autopsy brain was showed as follow 1) Most of tumor cells were changed coagulation necrosis, but a small part of tumor was still alive.
2) Tumor dose to make necrosis of the tumor volume composed of sphere about 7mm in diameter corresponding to the theoritical volume of light diffusion at the tip of the optical fiber was for 20 minutes, 250mw (300 joules), 630nm argon dye laser. 3) Therefore, some technical improvement is required to thorughly photordiate the tumor.
PDT can be used as an adjuvant to conventional therepy.