Photodynamic therapy (PDT) is one of the promising methods of cancer treatments. We used pheophorbide-a as a new photosensitizing agent and Q-switched Nd: YAG laser in which could be used as a laser beam. Pheophorbide-a is one of the derivatives origined in chlorophyll and has been reported biologically as safe and useful ones. The two main peaks of UV spectrum of Pheophorbide-a were seen at 410nm and 680nm. FlEp-2 cells, which were established from epidermoid carcimoma of human larynx, were used for PDT. PDT significantly inhibited the cell growth and additional effect with hyperthermia was recognized.
