In attempt to obtain basic data for endoscopical photochemotherapy (PCT) in combination with hyperthermia for gastric cancer, we investigated cytocidal effects of the combined treatment using a human cervical carcinoma (HeLa).
To test whether the order of the hyperthermia and PCT has any influence on the cytocidal effect of the combination therapy, hyperthermia (44°Cfor 15 min) was performed either before or after irradiation with argon laser (514.5nm).
The results indicate that cytocidal effects of PCT was potentiated by heat when the cells were heated after PCT, not when the cells were heated before PCT.
