Laser coronary angioplastyに関する実験的研究

抄録

To establish the method of coronary laser angioplasty by Argon, we have investigated that 1) the optimum condition of laser ablation, 2) relationship between the size of laser probe and the diameter of the vessel using bare ended probe (BEP) and metal tip probe (MTP) of 1.5mm in diameter. First of all, we examined the relationship between laser energy and the depth of crater on human cadaveric artery created by laser ablation. As a result, we were convinced that the most favorite condition of laser ablation is the repeated ablation, one of which is 1~5 watts in output and 1~2 seconds in ablation time using BEP, and 5~10 watts and 2 seconds using MTP. Secondly, laser ablation was carried out in the canine coronary artery under heating heart. In this experiment, perforations were seen in some cases using BEP, but no perforations and coronary spasms could be observed using MTP. However, if the size of metal tip was too large for the diameter of the vessel, the decrease of peripheral coronary artery pressure which would be induced by the vascular thermal constriction was clearly observed. So we examined intraluminal laser ablation using MTP in canine model, and confirmed that MTP/vessel diameter ratio should be 0.7 or less to avoid the vascular constriction.