抄録
As a part of the pharmacological studies on the embryonal stage, and in order to learn the influence of nicotine on the excretion of iodine, the author injected KI and nicotine separately and then in combination to the developing hens' eggs, and investigated the development of the chick embryos and the excretion of iodine in their allantoic fluids. Simultaneously, he conducted histopathological examinations of their livers. The following results were thus obtained.
1. Chick embryo injected with KI alone:
The single injection of 0.1 mg of nicotine did not cause any remarkable difference in the development from that of the controls. However, the development was found inhibited by the injections of more than 1.0 mg of nicotine. In the case of higher concentration of nicotine given, the incidence of hydropsis, malformation and death rate were found worse. KI did not seem to exercise any influence on the toxicity of nicotine against the development of chick embryo.
2. The injection of KI alone generally demonstrated a tendency to increase the amount of allantoic fluid compared with the control. However, the injections of nicotine alone or KI-nicotine combination caused the decrease in the amount of allantoic fluid. Thus, KI failed to inhibit the action of nicotine to decrease the amount of allantoic fluid.
3. The excretion of iodine into the allantoic fluid of the cases treated with KI was easily inhibited by the combination with nicotine. The degree of the inhibition became stronger as the concentration of the combined nicotine was raised. The phenomenon was found particularly strong when 3.0 mg of nicotine combined with KI was applied.
4. By the histological investigations, slight regressive degeneration in the hepatic cells was noted in the cases treated with KI alone. However, strong regressive degeneration was observed in the cases treated with nicotine alone and those treated with KI-nicotine combination. The degeneration was found stronger as the concentration of nicotine became higher.
