抄録
Studies were made on the influence of B1 and related compounds thiamine propyldisulfide (TPD) and thiamine allyldisulfide (TAD) on nicotine hydrops as well as on B1 metabolism. Stated in the following are the results obtained thereof:
1. B1 has an extremely weak inhibitory influence on the development of nicotine hydrops after 12th day of incubation, while TPD shows no such influence. The inhibitory influence of TAD is between the two.
2. Excretion of B1 into the allantoic fluid is markedly reduced by the administration of nicotine 3.0 mg.
3. When B1 was loaded under reduced B1 excretion, the excretion of B1 showed an increase in all stages of incubation in contrast to that of the loading of nicotine alone, but there was no comparison with the amount of excretion when B1 was loaded alone. Similar tendency was also observed with TPD. While, in the case of TAD, the total quantity of B1 excretion on the 15 th day and 18 th day of incubation in the eggs received combined administration was much larger than that of the control.
4. On loading nicotine, the B1 content of liver showed a remarkable reduce, while the total B1 content of liver was markedly large on administration of B1, TPD or TAD alone and this ten-dency was stronger in the case of the administration of TPD or TAD than that of B1.
5. Reduce in the B1 content of liver by the administration of nicotine was alleviated better by the administration of TPD or TAD, especially by TPD, than by the administration of B1.
