Ceruloplasminの合成と機能に関する研究
1974 年 34 巻 2 号 p. 115-123
詳細
1974 年 34 巻 2 号 p. 115-123
Studies of several factors influential over the biosynthesis of ceruloplamin were made on copper deficient rats and rabbits, because there are possiblities of ceruloplasmin being controlled by iron and hormones.
Copper promotes the biosynthesis of apo-ceruloplasmin, iron exerts an inductive effect on the biosynthesis of ceruloplasmin and inductive effect on the biosynthesis of ceruloplasmin, and estrogen promotes the biosynthesis of ceruloplasmin. Ceruloplasmin itself is inhibitory to the biosynthesis of ceruloplamin in the liver
These results provide evidence of a theory that ceruloplasmin acts promotively on mobilization of deposit iron in tissues and plasma iron turnover rate, but there is a feed-back mechanism between ceruloplasmin and iron metabolism that, in the presense of anemia, the serum ceruloplasmin is increased so as to enhance iron metabolism, but as anemia is recovered to normal, the serum ceruloplasmin itself suppresses the biosynthesis of ceruloplasmin, tc restore its normal level.
