In the case of design of impeller of compressor, the tuning of the geometry of the impeller is done keeping performance of the impeller. The frequency caused by rotation of the impeller also prohibit to coincident with characteristic frequency of the impeller. There are several line up of impellers for needs, and the tuning had been determined by designer who conducted many kind of examination for those impellers. Recently, response surface method utilizing design of experiments could estimate all of the geometry of impellers, and the method could find optimized geometry of the impeller satisfied with the operating conditions. In this study, we indicate effectiveness of response surface method utilizing design of experiments.