抄録
Porous beads of bioactive ceramics such as HAp(hydroxy apatite), TCP(tri-calcium phosphate) are considered to be promising as excellent scaffolds for cultivating bone cells. To realize this type of beads which maintains the function of scaffold with sufficient strength up to growth of new bone, and is expected to absorbed completely after the growth, α-TCP/ HAp functionally graded porous beads were fabricated. HAp is bioactive material which has both high strength and better tissue-adhesive properties, but that is not readily absorbed by the human body. On the contrary, α-TCP is highly bioabsorbable; it is quickly absorbed by the body, and, therefore, disappears before bone is completely replaced. Fabricated new beads are composed of α-TCP at the center and HAp at the surface, to control the solubility in living body. Bone cell adaptability of these beads were confirmed in vitro and the appropriate method for implantation was indicated.
