2P1-A24 細胞ビルドアップ型ウェットナノロボティクスの構築と機能創発 : 心筋細胞ゲルの機能制御に向けた薬剤投与及び形状制御

抄録

In this study, cardiomyocyte gels, which were consisted on cardiomyocytes and extracellular matrixes, were proposed as mechanical parts for a Wet Micro Robot. The drug stimulation and the control of the gel shape were evaluated to control the gel behavior. To control gel behavior, adrenaline, which excites cells, and nifedipine, which inhibits cell contractions, were added to the culture medium containing the gel. In the result, the contraction frequency was increased from 0.1Hz to 3.8Hz by the administration of adrenaline. In contrast, the contraction of the gel was stopped by the administration of nifedipine. Finally, the shape of cardiomyocyte gel was controlled by the PDMS mold shape. It was succeeded to fabricate the cardiomyocyte which had intersections and different cross section area from point to point.