細胞内物性計測を目指した磁気駆動ナノマシンの細胞内導入と制御

抄録

In this paper, we report on the intracellular introduction of nanomachines, with the final goal of measuring intracellular physical properties by magnetically driven nanomachines. In this study, a microchip and centrifugal force were used to introduce nanomachines into a red blood cell. The microchip was fabricated with a structure of SU-8 on a slide glass. Micropockets are formed in the structure to hold red blood cells. The size was a square with one side of 10 μm considering the size of a red blood cell. We dropped the solution containing red blood cells and nanomachines into the inside of the structure and cover the structure with a cover glass. Thereafter, the microchip was centrifuged. Due to centrifugal force, red blood cells and nanomachines move toward micropockets, at which time nanomachines are introduced into the red blood cells. As a result of microscopic observation, nanomachine was introduced into red blood cells.