磁気駆動型ナノマシンの高効率細胞内導入を目指したデバイスの開発

抄録

In this paper, we proposed a device for high effective internalization of magnetically driven nanomachines into a single cell. Carbon nanocoil sputtered Ni is used as a nanomachine. The nanomachine can be driven by rotating magnetic field. In order to increase efficiency of internalization of nanomachine into a cell, we proposed micro square patterns pasted cell non- adhesion polymer on convex regions as a cell culture environment that adhered cells at the bottom of square patterns efficiently take in nanomachines attracted to surface with vertical magnetic field. We succeeded fabrication of 50 μm and 100μm square patterns on a biocompatible material.