臓器を対象とした圧力分散型光化学細胞膜穿孔システム

抄録

Our photochemical cell membrane perforation method is new approach for mass cell processing, eg. cell therapy or regenerative medicine. The method requires homogeneous control of cell attaching pressure of nano brush shaped cell membrane perforator which contains photosensitizer, but it was hard because almost the cell size are micrometer scale and its structure is weak. We made the fluid-packed perforator to homogenize the applying pressure, based on Pascal's principle. This perforator has flexible surface which can adopt variations of cell layer on culture dishes. In this research, we developed the extended system for tissues and will report a trial effort on mouse tissues.