がん細胞スフェロイド群を用いた抗がん剤ペプチド探索デバイス

―流体挙動の観察とスフェロイド群の構築―

抄録

Tumor specific binding peptides have the potential to alleviate the side effects of anti-cancer drugs. To reduce the laborious effort for peptide screening, some microfluidic devices were proposed using adherent cancer cells or protein coated beads as the targets of peptides. We have developed a microfluidic peptide screening device with a group of cancer cell spheroids as the targets of peptides, which are closer to in vivo tumors. Channels are designed based on the fluid behavior to trap minute micro scale spheroids in the chambers of the device. The experiment results demonstrate that the fluid behaves as designed and the device can successfully form a group of spheroids.