1964 年 16 巻 6 号 p. 564-571
The patient (29 years, housewife) suffered for a long time from typical vitamin B2 group defficiencies, but from Feb. 1961 pantothenic acid defficient symptoms also appeared. Thereafter the pantothenic acid defficient symptoms appeared off and on for about a year and 9 months. She was then treated with various kinds and doses of pantothenic acid derivatives, such as, D-L (or D-)-alcium pantothenate or D-L (or D-)-pantothenol and the effect of each derivatives was observed.
1) 100mg of D-calcium pantothenate or D-pantothenol cured the symptoms readily. In the case of D-L-derivative 200mg had the same effectiveness.
2) When 100mg of D-calcium pantothenate or Dpantothenol was given in the early stage or reappearance of pantothenic acid defficient symptomes, the effectiveness was remarkable.
3) Pantothenic acid defficient symptomes and nicotinic acid defficient symptoms readily recovered when given orally lange amounts (100mg) of the defficient vitamins. On the other hand vitamin B2 defficient symptoms required about one to several weeks' treatment and vitamin B1 defficient symptoms required several months treatment.