生活習慣・生活習慣病とAlzheimer病

抄録

Lifestyle disease and social inactivity used to be considered as the principal cause of aging–related cognitive decline in our country. More recently, however, research emphasis has shifted to studies of neurodegenerative disease. It is now widely accepted that lifestyle disease accelerated the onset and progress of Alzheimer's disease (AD). No curative treatment is available, but epidemiological research provides a substantial amount of evidence of modifiable risk and protective factors that can be addressed to prevent or delay onset of AD and dementia. Risk of late–life dementia is determined by exposures to multiple factors experienced over the life course, and the effect of specific risk/protective factors depends largely on age. Medical and lifestyle interventions and promote social, mental, and physical activities aimed at increasing the cognitive reserve. The treatments for lifestyle disease represent an important avenue of approach to help slow or prevent the onset and progression of AD.