日本口腔インプラント学会誌
Online ISSN : 2187-9117
Print ISSN : 0914-6695
ISSN-L : 0914-6695
原著
ヒト正常骨由来骨芽細胞様株(SV-HFO)に与えるパルス電磁場刺激の影響
八島 明弘越智 守生広瀬 由紀人賀来 亨坂口 邦彦
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ジャーナル フリー

2000 年 13 巻 1 号 p. 29-37

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抄録
It has been demonstrated that pulsing electromagnetic fields (PEMFs) have osteogenic action in vitro and in vivo. It has also been shown that PEMFs stimulated mRNA expression of bone morphogenetic protein (BMP)-2 and -4 in chick embryonic calvaria. However, the effects of PEMFs on the gene expression of other BMPs are still unclear. The current study was undertaken to examine the effects of PEMFs on the gene expression of BMPs (BMP-1 to -7) in SV 40 large T antigen immortalized human osteoblastic cells (SV-HFO cells) by reverse transcription-polymerase chain reaction(RT-PCR). When the cells were 75% confluent, the cells were continuously exposed by the PEMFs for l and 6 hr, respectively. PEMFs reproducibly and markedly increased the mRNA for BMP -2, -4, and -5 in SV-HFO cells after 6 hr. These results indicate that the osteogenic effect of PEMFs may be, in part, mediated by up-regulation of bone morphogenetic protein -2, -4, and -5 in human osteoblastic cells in vitro.
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© 2000 公益社団法人日本口腔インプラント学会
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