抄録
A 17-year-old male developed direct Coomb's positive hemolytic anemia, in which hemoglobin level became 6.8g/dl from 14.5g/dl, while receiving cefuroxime (CXM) therapy.
CXM was administrated after the open reduction and fixation for mandibular fracture. Hemoglobinuria occurred with abdominal pain 24 hours after CXM administration. The patient was treated with massive fluid transfusion and forced diuresis to prevent renal failure. Twenty days later, hemoglobinuria disappeared and direct Coomb's test became negative.
Type II allergic reaction on the red blood cell membrane to CXM might have caused severe immunological hemolysis.
