歯科薬物療法

口腔外科各種疾患手術症例に対するフィブリン糊 (ベリプラスト P) の使用経験

京極順二, 水城春美, 神田稔郎, 増田裕之, 石部幸二, 高橋喜浩, 河野憲司, 松島凛太郎, 柳沢繁孝, 清水正嗣

1993 年 12 巻 2 号 p. 73-80
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.73

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This report describes a clinical application of fibrin adhesive (Beriplast^®P), which consists of high concentrated human fibrinogen, thrombin, and blood coagulation factor XIII. This fibrin adhesive was used for the purpose of hemostasis, adhesion, packing, and protection of the wound in 78 cases of various operations in the oral and maxillofacial region. The clinical results were good in 73 cases, and poor in 5 cases. The side effects were not observed in any of the cases in which the fibrin adhesive was employed.
The results support the fact that Beriplast^®P is useful for the oral and maxillofacial surgery.

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抗生物質による溶血性貧血の一例

村上通隆, 橋本温, 谷岡博昭

1993 年 12 巻 2 号 p. 81-84
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.81

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A 17-year-old male developed direct Coomb's positive hemolytic anemia, in which hemoglobin level became 6.8g/dl from 14.5g/dl, while receiving cefuroxime (CXM) therapy.
CXM was administrated after the open reduction and fixation for mandibular fracture. Hemoglobinuria occurred with abdominal pain 24 hours after CXM administration. The patient was treated with massive fluid transfusion and forced diuresis to prevent renal failure. Twenty days later, hemoglobinuria disappeared and direct Coomb's test became negative.
Type II allergic reaction on the red blood cell membrane to CXM might have caused severe immunological hemolysis.

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各種口腔内細菌の発育阻止にいたる温度と時間の影響

野村典生, 新井高, 中村治郎

1993 年 12 巻 2 号 p. 85-88
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.85

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The aim of this study was to investigate the effect of incubating temperature and time on oral bacterial growth in vitro.
Incubating time and temperature were established as follows respectively; 60°C, 70°C, 75°C, and 80°C 30 min. each, 75°C for 15 min. and 20 min, additionally.
Twenty-nine bacterial species were tested.
Incubating time of 20min. at 75°C was enough to pasteurize all oral bacterial growth.

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歯性感染症から分離されたOral Streptococci 99株のCefuzonam感受性

毒島保信, 小林寅〓

1993 年 12 巻 2 号 p. 89-90
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.89

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The susceptibility of cefuzonam sodium (CZON) against 99 stains of oral Streptococci which were isolated from the odontogenic infections was measured according to the standard method of Japan Society of Chemotherapy
Ninety-seven percent of them showed that the MIC is less than 0.39μg/ml, which means the susceptibility of CZON proved quite favorable.
Considerting the pharmacokinetic parameter of CZON, the agent satisfies the standard necessary for the transient bacteremia during and after the dental surgical procedure.

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口腔扁平上皮癌患者に対するTegafur徐放性製剤 (Sunfural S) 投与時の副作用の検討

深川淳至, 篠原正徳, 中村誠司, 嶋田誠, 岡増一郎

1993 年 12 巻 2 号 p. 91-95
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.91

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Adjuvant chemotherapy has recently become an effective measure for treatment of malignant tumors. Sunfural^® S is a slow-releasing Tegafur capsule, which is a masked compound of 5FU, and was developed for the purpose of elevating the effect and reducing the side effects of Tegafur.
We report here side effects of Sunfural^® S possibly caused by the long-term administration of this agent to 26 oral S.C.C.C patients. Side effects were seen in 9 patients (34.6 %) . Two patients experienced two different side effects. Liver dysfunction in 3 cases, loss of appetite in 2 cases, pigmentation in 2 cases, eruption, photosensitivity, decrease of WBC, or decrease of platelets in 1 case. The occurrence of these side effects showed no relevance to patients' age, sex, dosage, or duration of administration. All patients recovered in several weeks after the administration had been stopped. These results suggested the usefulness and the safety of Sunfural^® S as an adjuvant chemotherapeutic agent.

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埋伏智歯抜歯後疼痛に対するロキソプロフェンソディウム (ロキソニン) の臨床評価

内山公男, 朝波惣一郎, 須佐美英作, 高森康次

1993 年 12 巻 2 号 p. 96-103
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.96

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Loxoprofen sodium (Loxonin^®) is one of the anti-inflammatory analgesics of the phenylpropionic acid group. Its side effects on digestive organs are less than those of other analgesics because of prodrug. In thes study, for 50 cases with postexodontic pain, the analgesic effect and safety of Loxonin^® were clinically evaluated after impacted wisdom tooth extraction.
1. The frequency of the analgesic effect was 82 % according to impressions of patients, and 80 % by the judgment of the doctor.
2. Nobody knew the side effects of the drug.
3. The frequency of the reduction of a pain was 76 %, and the duration of effect was 84 %, each those rates were over “effective”.
From the results of this study, it was suggested that Loxonin^® is effective and safe for treatment of postexodontic pain.

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顎口腔顔面領域における術後栄養管理 (第I報)

―新経腸栄養剤T-330の臨床使用経験―

武田則昭, 實成文彦, 長畠駿一郎, 合田恵子, 鶴田敬司, 浅川冨美雪

1993 年 12 巻 2 号 p. 104-117
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.104

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In the case of post-operated nutritional maintenance in oral and maxillofacial region, enteral tube nutrition (T-330) was applied for a week from the day after operation. Administered cases were 6 cases for mandibular/maxillary bone fracture, 2 cases for mandibular protrusion and 1 case for temporomandibular joint ankylosis.
The results were as follows :
1. If slight side effects were included, side effects such as loose feces (2 cases), diarrhea (3 cases), abdomen inflation (2 cases), nausea (3 cases) and vomiting (1 case) were confirmed during the administration week. But, symptoms in each case were so slight that neither reduction in amount of administration nor interruption was performed.
2. In the case with the side effects of loose feces or diarrhea, a large quanity of total dosage and high concentration were given at the beginning of administration of T-330.
3. Under the unstable condition with injury and operation, a sufficient and balanced nutritional supply was realized by T-330 without remarkable side effects.
4. The results of general clinical examination were normal after one week of administration of T-330.
From the above-mentioned results, we concluded that T-330 could be suitable for nutritional maintenance of the patient operated for oral-maxillofacial diseases, esp., mandibular fracture.

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顎口腔顔面領域における術後栄養管理 (第II報)

―新経腸栄養剤T-330の臨床使用後のアミノグラムの術前後における変化について―

武田則昭, 實成文彦, 長畠駿一郎, 合田恵子, 鶴田敬司, 浅川冨美雪

1993 年 12 巻 2 号 p. 118-129
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.118

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In the case of post operation nutritional maintenance in oral and maxillofacial region, enteral tube nutrition (T-330) mainly containing di-and tripeptide was applied for a week from the day after operation. Administered cases were 6 cases for mandibular/maxillary bone fracture, 2 cases for mandibular protrusion, and 1 case for temporomandibular joint ankylosis.
The results concerning plasma amino acid, serum albumin, and total protein were as follows :
1. In all cases, plasma amino acid after a week of administration of T-330 showed an increasing tendency when compared to that of preoperation. Furthermore plasma aminograms were well-balanced.
2. Serum albumin, serum total protein and fisher ratio in postoperation (7 days) showed no significant difference when compared to those in preoperation. Each examination value was within the normal limit.
3. Plasma 3-methylhistidines were N. D. (non-detective) but within the normal limit both in pre-and postoperation.
4. The results in fresh fractured mandibule/maxilla (6 cases) and comparatively older fractured mandibule (1 case) had the same tendency as those mentioned above.
From the above-mentioned results, we concluded that T-330 could be a suitable source of nitrogen for nutritional maintenance of the patient operated on for oral-maxillofacial diseases.

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ピペラシリン (PIPC) の使用によりアレルギー (発熱) を生じた2例

森川雅之, 岩田雅裕, 小山茂樹, 高木慎, 西嶋克巳

1993 年 12 巻 2 号 p. 130-134
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.130

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All medicines have some side effects. Medicines are used when the effect is more than the side effect.
In the cases of antibiotics, their effect for infection is very large, so usually, in consideration of the effect, the side effect does not become a subject of discussion. But drug fever is one side effect that may take a turn for the worse, if we mishandle it.
The fever in administration of medicine is called drug fever, universally it occurs due to the method of administration, physiological function of medicine, change of system for regulation of body temperature, factor of patient, and allergy.
This has been a report of drug fever as side effect, allergy, after administration of piperacillin sodium.
In the course of treatment for infection, body temperature became normal, occasionally rising again. As fever is the main symptom of infection, judgment of fever, whether it is caused by a drug or resistant bacteria, is very difficult.
Clinically, in the case of an unknown fever, according to the circumstances, not only catching the situation of patient but suspending the administration of medicine is necessary.

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低カルシウム環境下培養新生仔ラット下顎第一大臼歯歯胚におけるDNA合成能の変化

松本章, YOH HISADA, YOSHITAKA YOSHIMURA, KUNIAKI SUZUKI

1993 年 12 巻 2 号 p. 135-139
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.135

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新生仔ラットの左右下顎第一臼歯歯胚を無菌的に摘出し左側大臼歯を正常培養液 (αMEM) (対照群) , 右側大臼歯を低Ca培養液 (低Ca群) で通法により培養し, 8日目に〔³H〕thymidine (1μCi/ml) を両群の培養液に添加し, 更に24時間並びに48時間培養した.培養後, 歯胚をホモジナイズし, 放射能を測定した.その結果, 両群とも培養24時間, 48時間と経時的に〔³H〕thymidineの取り込みの減少が示されたが両培養期間とも低Ca群における方が対照群より〔³H〕thymidineの取り込み量は増加していた.減少の程度は対照群において低Ca群と比べて, より高いことが示された.また24時間並びに48時間の両培養期間において〔³H〕thymidineの取り込み量は対照群に比べて低Ca群において, より高いことが示された.この取り込み量の低Ca群に対する比率はいずれの培養期間においても1より大きく, 低Ca群での取り込み量が対照群と比べ, より増大していることが認められた.その程度は48時間の培養期間における比率が24時間のそれに比べ, より高い傾向のあることが示された.これらの事実から低カルシウム環境下に歯胚が置かれるとDNA合成能が経時的に低下はするもののその取り込み率は, 対照群に比べ上昇していることが示され, 歯胚が異常な環境に抗して, 正常機能を維持しようとする何らかの機構が作動していることが示唆された.

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エアータービンハンドピースの消毒に関する研究

1.とくに消毒用アルコールを吸引させた場合の効果について

塩野真, 林誠, 前田圭司, 唐沢竜祐, 紙本篤, 小島弘光, 服部嘉郎, 斎藤毅

1993 年 12 巻 2 号 p. 140-145
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.140

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Air turbine handpiece is indespensable for ordinary dental clinical works. As the air turbine handpiece system contains a retraction valve, it has been hypothesized that the feature causes the dental unit to draw or aspirate cooling water, saliva, and blood back into the water line.
For that reason, the air turbine system has a high risk for cross infection in the dental office.
The purpose of this study was to determine the microorganisms in the air turbine handpiece after dental clinical use, and the efficiency of simple disinfection for the air turbine handpiece with an alchoholic disinfectant.

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医薬関連情報Q&A

1993 年 12 巻 2 号 p. 146-147
発行日: 1993/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.12.146

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