抄録
For the purpose to prevent the serious influenza infection among newborns, the following experiment to testify the possibility of the materno-fetal immunization against influenza were performed. Pregnant women at their 8-9th month of gestation were injected with commercial trivalent (A1, A2, B) type vaccine and adjuvant added bivalent (A2, B) type vaccine, specially prepared by Chiba Serum Institute for experimental purpose. These vaccine have the potency of 100CCA/ml and 200CCA/ml per each type, respectively. The mother bloods taken just before the injection and at delivery, and cord bloods and colostrum collected at delivery were tested for their contents of influenza CF-V, CF-S and HI antibodies.
As the results, the increase of CF-V and HI titer in the mother bloods were observed after vaccine injection, especially when subcutaneous 1ml injection following two intradermal 0.1ml injection of routine commercial vaccine, or when 0.5ml adjuvant added vaccine were injected subcutaneously. On the contrary, the increase of CF-S titers were not observed.
In the cord bloods somewhat higher titers of CF-V, somewhat lower titers of CF-S and nearly equal titer of HI antibodies were demonstrated, as comparing with those in the mother bloods.
In the mother colostrum, HI antibodies of lowere titers comparing with those of mother bloods were demonstrated.
From above data it became evident, that the materno-fetal immunity against influenza is completely established by active immunization of pregnant women at their 8-9th month of gestation.
