ギラン・バレー症候群を呈する流行性多発生神経根炎及び麻痺ポリオ患者のポリオウイルス中和抗体に関する研究

抄録

The paired sera obtained from two groups of patients with polio and with polyradiculoneuritis so-called Guillain-Barré syndrome (G. B.) encountered in the Setouchi area 1953-1955 were attested for the polio antibody of three types employing. tissue culture HeLa tubes. The objecives of this study were to clarify the relation of these two entities. The four piloting marks would be of significance; 1) polio antibody of G. B. against one of three types were revealed in 21 cases out of 24 (87.5%) while 3 cases (12.5%) of negative reading. This percentage is in good accordance with the polio antibody distribution in the placebo groups, 2) type distribution of G. B. was in the range of placebo groups, namely type I 11 (45.8%) II 11 (45.8%) and III 13 (54.2%). 3) yearly analysis of presence of polio antibody of G. B. was revealed in the vicinity of placebo groups, 4) This might be compared with the 100% positive reading in the polio antibody titer of paralytic polio groups against one of three types. 4 cases among these 23 cases showed double types (17.4%). Type I 14 cases (60.9%) II 5 (21.7%) and III (34.8%). The yearly variation of the type distribution manifested predominancy of type II in 1953, type I in 1954, type I and III equally in 1955.
Accordingly it would appear probable that G. B. could be of dissimilar entity from polio, and the presence of polio antibody in G. B. would be of inapparent infection of polio in the process of continuous exposure to the polio virus as illustrated in the placebo groups. The data on the placebo groups will be shown in the following paper.