ウイルス
Online ISSN : 1884-3433
Print ISSN : 0042-6857
ISSN-L : 0042-6857
ポリオウイルスとコクサキーウイルスの干渉現象に関する研究 (I)
成熟マウス実験的ポリオに対するコクサキーウイルスの影響
大原 俊夫
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ジャーナル フリー

1958 年 8 巻 2 号 p. 137-141

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The mouse adapted strains of polio Lansing, Leon and Mahoney three types and the Coxsackie virus Okumoto strain (A-2) and Dohi strain (A-19) which were obtained from the patient with typical Guillain-Barré syndrome were crossingly challenged through discernible route of adult mice to attest the interference.
1) The positive interference was observed in the group inoculated with C. V. Okumoto strain 106LD50 previously and challenged with Lansing strain 50LD50 after 4 days.
2) No interference was observed in the following style: a. subcutaneous injection of Okumoto strain followed by the intracerebral route of Lansing strain after O, 2 and 6 days. b) intracerebral route of Okumoto strain followed by same route of Lansing strain after O, 2, 4 and 6 days. c) subcutaneous and intracerebral route of Dohi strain followed by intracerebral route of Lansing strain. d) subcutaneous or intracerebral of Okumoto or Dohi strain followed by intraspinal route of Mahoney strain after 4 days. e) intracerebral or subcutaneous route of Okumoto or Dohi strain followed by Leon strain after 4 days.

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