抄録
The periodontal ligament is a typical noncalcified connective tissue that functions in tooth support and lies between cementum and alveolar bone which are mineralized tissues. This tissue is involved in the remodeling processes associated with the development of periodontium, tissue regeneration and physical stresses such as occlusion and mastication. The cells derived from periodontal ligament were characterized with respect to the osteoblastic phenotypes which demonstrated the expression of bone type alkaline phosphatase (ALPase) and bone proteins, the cellular responses of calcium regulatory hormones such as 1,25(OH)2D3 and parathyroid hormone (PTH), and the ability to form mineralized-like nodules. The effects of mechanical stress on the cellular processes of human periodontal ligament fibroblast-like cells (HPLF) were investigated in relation to the regulation of cell proliferation and differentiation. The periodontal ligament may comprise a heterogeneous cell linage which is a renewal cell system in remodeling and regeneration.
