カプセル製剤化したバナジウム錯体の吸収改善

抄録

Patients with diabetes mellitus are increasing in the world. Recently, we have reported that vanadyl ion and its complexes normalize the blood glucose levels of streptozotocin-induced type 1 diabetic rats. When they will be used clinically in the future, it is indispensable to understand the pharmacokinetic behavior of vanadyl compounds. Therefore, we examined the features of vanadyl states in the blood of healthy rats after oral or intraileal administration of three vanadyl compounds (VS, VO (pic)₂ and VO (6mpa)₂) by using electron spin resonance, and found that vanadyl compounds are mainly absorbed from the ileum. On the basis of the results, we attempted to use the enteric coated capsule containing VO (6mpa)₂. Bioavailability of VO (6mpa)₂ was improved by the capsulation, and high vanadyl concentrations in the blood were kept continuously. In conclusion, enteric coated capsulation of vanadyl complexes is a useful method to treat diabetes mellitus.