Absorption, Tissue Acccmulation,and Toxicity of Vanadium in Mature Hamsters and Developing Chick Embryos Administered with Various Vanadium Compounds

抄録

Absorption and tissue accumulation of vanadium were determined in mature hamsters fed purified diets containing NaVO₃, VOSO₄ or vanadyl-cysteine methyl ester at each 10 and 20 ppm as V for a week. The absorption of V from NaVO₃ was slightly higher than that from VOSO₄ or vanadyl-cysteine methyl ester. Tissue accumulation of V was the highest in the kidneys and second highest in the liver. In order to know the toxicity of vanadate and vanadyl compounds and to find effective agents to cope with the toxicity, a model system using fertile chick eggs was established. Aqueous solution of those V compounds and/ or aqueous solution of EDTA-2Na were separately introduced into the air sacs of 14-day-old fertile eggs through holes in eggshells and the treated eggs were further incubated for 2 or 5 days. The accumulation of V in the legs (metatarsus) and toes became an indicator of V absorption and both the embryonic growth and the survival rate were adversely affected by the administration of V compounds. In this experiment vanadyl appeared to be more toxic than vanadate. When VOSO₄ and EDTA-2Na were separately introduced into the air sacs, the complex was formed in the air sacs and the toxicity of V was greatly alleviated since such a complex as VO-EDTA was not absorbed from the air sacs to the embryos as efficiently as VOSO₄ itself.