DOSE-RELATED RESPONSE OF MOUSE MAMMA TO SOME PHENOTHIAZINE DRUGS

Abstract

The dose-related response of the mammary growth was studied in immature ICR-JCL female mice given 0.03 μg of estradiol per animal subcutaneously, and 0.005-1.0 mg of either of the following phenothiazines (chlorpromazine, levometh iomeprazine, promethazine, perphenazine, thioridazine and propericiazine) per 10g of body weight was given orally once a day for 9 days starting on the 5th day after ovariectomy. The right second mamma of the chest was used to compare the hypertrophic effects. All the phenothiazines used produced mammary growth in the intensity sequence of thioridazine &gt chlorpromazine &gt promethazine &gt propericiazine &gt perphenazine &gt levomethiomeprazine. An optimal dose of each of the phenothiazines required to produce the maximum hypetrophy of the mammary gland was examined. From the results obtained, the relationship between the side-chain moiety of the compounds and the mammary growth activity could not be revealed.