Experiment on Anthelmintic Effect of a Thenium Preparation on Canine, Hookworms and Canine Ascarides

抄録

Ancaris, a proprietary preparation of thenium, was examined for anthelmintic effect on 20 dogs infected with canine hookworms and 12 dogs infected with canine ascarides. One tablet of it was administered to adult dogs weighing less than 5kg, two tablets to those weighing less than 10kg, and three tablets to those weighing less than 15kg. Puppies weighing 480 to 1, 500g were given one-third to one half of a tablet twice a day in the morning and in the evening.
The anthelmintic effect was determined by comparing the number of worms remaining in the body at autopsy conducted on adult dogs 7days after medication and on puppies 4 days after medication and the number of worms excreted daily after medication. The number of eggs excreted per gram of feces (E. P. G.) counted twice before and three times after medication was also taken into consideration in the case of adult dogs.
As a result, worms were removed and egg excretion became negative at rather high rates in most of the adult dogs. The rate of removal of hookworms was 84.6 per cent. Excretion of worms was observed 2 to 3 days after medication. E.P. G. was also reduced around this period. The rate of removal of ascarides was 76.3 per cent in 4 puppies given one-third of a tablet, 96.3 per cent in 4 puppies given one half of a tablet, and only 75.0 per cent in 5 adult dogs. In the case of whipworms, egg excretion became negative at a rate of 47.0 per cent, but the rate of removal of worms was 9.8 per cent. Ancaris was not effective for the removal of tapeworms.
As a side effect of Ancaris, vomiting was exhibited only by one dog. Therefore, this preparation was proved to be a reliable, effective anthelmintic against hookworms and ascarides.