Identification and Sequence Analysis of the Marek's Disease Virus Serotype 2 Gene Homologous to the Herpes Simplex Virus Type 1 UL52 Protein

Yoshihiro IZUMIYA; Hyung-Kwan JANG; Jin-Shun CAI; Yorihiro NISHIMURA; Kazuya NAKAMURA; Yoshinori TSUSHIMA; Kentaro KATO; Takayuki MIYAZAWA; Chieko KAI; Takeshi MIKAMI

doi:10.1292/jvms.61.683

Yoshihiro IZUMIYA, Hyung-Kwan JANG, Jin-Shun CAI, Yorihiro NISHIMURA, Kazuya NAKAMURA, Yoshinori TSUSHIMA, Kentaro KATO, Takayuki MIYAZAWA, Chieko KAI, Takeshi MIKAMI

著者情報

Yoshihiro IZUMIYA
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Hyung-Kwan JANG
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Jin-Shun CAI
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Yorihiro NISHIMURA
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Kazuya NAKAMURA
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Yoshinori TSUSHIMA
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Kentaro KATO
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Takayuki MIYAZAWA
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Chieko KAI
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Takeshi MIKAMI
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

キーワード: Marek's disease virus serotype 2, transcript, UL52

ジャーナルフリー

1999 年 61 巻 6 号 p. 683-687

DOI https://doi.org/10.1292/jvms.61.683

詳細

抄録

The gene of Marek's disease virus serotype 2 (MDV2) homologous to the UL52 gene of herpes simplex virus type 1 (HSV-1) was identified and characterized. The MDV2 UL52 homologous gene encodes 1, 071 amino acids with a molecular weight of 118.7 kDa, which includes putative metal-binding site and overlapping region with the UL53 homologous gene. Although a putative polyadenylation signal sequence was found in the downstream of the MDV2 UL52 gene, a MDV2 UL52 DNA probe reacted only with the polycistronic 6.3 kb transcript, representing the UL52 and the downstream genes of UL53 and UL54. Transcriptional pattern of this region of MDV2 was somewhat different from corresponding regions of HSV-1 and infectious laryngotracheitis virus.

責任著者(Corresponding author)

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