Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Analysis of the Epitopes on Staphylococcal Enterotoxin A Responsible for Emetic Activity
Dong-Liang HUKatsuhiko OMOEMona Hamed Husien SALEHKatsuhiko ONOShunji SUGIIAkio NAKANEKunihiro SHINAGAWA
ジャーナル フリー

2001 年 63 巻 3 号 p. 237-241


To identify which region of staphylococcal enterotoxin A (SEA) is responsible for the emetic activity, twelve synthetic peptides corresponding to the entire SEA amino acid sequence and their respective anti-peptide antibodies were prepared and tested. The anti-peptide antibodies were tested for neutralization of SEA-induced emesis in Suncus murinus (Shrew mouse). The results indicate that SEA-induced emesis was neutralized by the mixture of three anti-peptide antibodies to A-7 (corresponding to amino acid residues 121-140), A-8 (141-160) and A-9 (160-180). These findings suggest that the regions corresponding to residues 121-180 may be the epitopes responsible for the emetic activity of SEA.


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