Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
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Peripheral Mononuclear Cell Response in Japanese Black Calves after Oral Administration of IFN-α
Hiromichi OHTSUKAMayumi TOKITAKatsushige TAKAHASHIMachiko MASUIMasayuki KOHIRUIMAKITomohito HAYASHITakaaki ANDODaisaku WATANABESeiichi KAWAMURA
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2006 年 68 巻 10 号 p. 1063-1067

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To investigate the effects of oral administration of an interferon (IFN)-α drug on the immune reaction of healthy Japanese Black (JB) calves, peripheral leukocyte populations and their ability to produce cytokine mRNA were analyzed after oral administration of IFN-α. Fourteen calves fed in one herd were divided into two groups; seven calves were orally administered 0.1 g/day of IFN-α from the day of birth to day 5 on each day (group 1, N=7), and the other seven calves were used as the control (group 2, N=7). Blood samples were collected from the jugular veins of all calves before administration and in weeks 1, 2, 4, 8, and 16 after birth. The number of MHC class II+CD14+ monocytes in the leukocytes population of group 1 increased gradually after birth, and significantly higher numbers were detected in week 4 compared with group 2. MHC class II-CD14+ monocytes in group 1 peaked in week 1, and a significant increase was detected compared with group 2. The level of IL-12 in the cytokine mRNA of group 1 increased gradually between weeks 1 and 2, and a significantly higher level of IL-12 was found compared with group 2. These results suggest that oral administration of IFN-α induces activation of the monocyte functions in JB calves.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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