Genetic Analysis of Phosphoprotein and Matrix Protein of Rabies Viruses Isolated in Brazil

Yuki KOBAYASHI; Hiromi OKUDA; Kana NAKAMURA; Go SATO; Takuya ITOU; Adolorata A. B. CARVALHO; Marlon V. SILVA; Carla S. MOTA; Fumio H. ITO; Takeo SAKAI

doi:10.1292/jvms.69.1145

Virology

Genetic Analysis of Phosphoprotein and Matrix Protein of Rabies Viruses Isolated in Brazil

Yuki KOBAYASHI, Hiromi OKUDA, Kana NAKAMURA, Go SATO, Takuya ITOU, Adolorata A. B. CARVALHO, Marlon V. SILVA, Carla S. MOTA, Fumio H. ITO, Takeo SAKAI

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Keywords: Brazil, genetic analysis, matrix protein, phosphoprotein, rabies virus

JOURNAL FREE ACCESS

2007 Volume 69 Issue 11 Pages 1145-1154

DOI https://doi.org/10.1292/jvms.69.1145

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Abstract

To investigate the genetic characteristics of phosphoprotein (P) and matrix protein (M) genes of variable rabies virus (RV) prevalent in Brazil, the authors genetically characterized the P and M genes from 30 Brazilian RV field isolates. Phylogenetic analysis based on the P and M genes revealed the presence of six RV variants that consisted primarily of three insectivorous bats, the vampire bat, dog and fox in Brazil. Specific amino acid substitutions corresponding to these phylogenetic lineages were observed, with Asp₄₂ and Glu₆₂ in the P protein found to be characteristic of Brazilian chiroptera- and carnivora-related RVs, respectively. Amino acid sequence motifs predicted to associate with a viral function in the P and M proteins were conserved among Brazilian RV variants.

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