Hypophysectomy for a Dog with Coexisting Cushing's Disease and Diabetes Mellitus

Hirokazu ISHINO; Yasushi HARA; Takahiro TESHIMA; Shigeki TANAKA; Susumu TAKEKOSHI; Yoshinori NEZU; Yasuji HARADA; Takuya YOGO; Toshinori SAKO; Hidekazu KOYAMA; Akira TERAMOTO; Robert Y. OSAMURA; Masahiro TAGAWA

doi:10.1292/jvms.09-0348

Surgery

Hypophysectomy for a Dog with Coexisting Cushing's Disease and Diabetes Mellitus

Hirokazu ISHINO, Yasushi HARA, Takahiro TESHIMA, Shigeki TANAKA, Susumu TAKEKOSHI, Yoshinori NEZU, Yasuji HARADA, Takuya YOGO, Toshinori SAKO, Hidekazu KOYAMA, Akira TERAMOTO, Robert Y. OSAMURA, Masahiro TAGAWA

Author information

Hirokazu ISHINO
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
Yasushi HARA
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
Takahiro TESHIMA
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
Shigeki TANAKA
Alpha Animal Hospital
Susumu TAKEKOSHI
Department of Pathology, Tokai University School of Medicine
Yoshinori NEZU
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
Yasuji HARADA
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
Takuya YOGO
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
Toshinori SAKO
Department of Veterinary Nursing, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
Hidekazu KOYAMA
Division of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
Akira TERAMOTO
Department of Veterinary Nursing, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
Robert Y. OSAMURA
Department of Pathology, Tokai University School of Medicine
Masahiro TAGAWA
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
Author's Organization：
Department of Neurosurgery, Nippon Medical School

Keywords: canine, Cushing's disease, diabetes mellitus, hypophysectomy, pituitary

JOURNAL FREE ACCESS

2010 Volume 72 Issue 3 Pages 343-348

DOI https://doi.org/10.1292/jvms.09-0348

View "Advance Publication" version (December 1, 2009).

Details

Abstract

An 11-year-old male mixed breed dog diagnosed with Cushing's disease and diabetes mellitus was treated by hypophysectomy. After surgery, the hypercortisolemia disappeared and the diabetes status improved. The insulin requirement to control hyperglycemia gradually decreased. At 12 weeks after surgery, there was no requirement for insulin and we suspected the diabetes was completely resolved. In the present case, diabetes mellitus seems to be secondary to Cushing's disease. In conclusion, this mixed breed dog with coexisting Cushing's disease and diabetes mellitus is the first case showing the effectiveness of hypophysectomy to treat diabetes mellitus secondary to Cushing's disease in dogs.

Corresponding author

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