Prevalence of Equine Herpesvirus Type 1 Strains of Neuropathogenic Genotype in a Major Breeding Area of Japan

Koji TSUJIMURA; Takeshi OYAMA; Yoshinari KATAYAMA; Masanori MURANAKA; Hiroshi BANNAI; Manabu NEMOTO; Takashi YAMANAKA; Takashi KONDO; Masakatsu KATO; Tomio MATSUMURA

doi:10.1292/jvms.11-0140

Virology

Prevalence of Equine Herpesvirus Type 1 Strains of Neuropathogenic Genotype in a Major Breeding Area of Japan

Koji TSUJIMURA, Takeshi OYAMA, Yoshinari KATAYAMA, Masanori MURANAKA, Hiroshi BANNAI, Manabu NEMOTO, Takashi YAMANAKA, Takashi KONDO, Masakatsu KATO, Tomio MATSUMURA

Author information

Koji TSUJIMURA
Epizootic Research Center, Equine Research Institute, Japan Racing Association
Takeshi OYAMA
Hokkaido Hidaka Livestock Hygiene Service Center
Yoshinari KATAYAMA
Epizootic Research Center, Equine Research Institute, Japan Racing Association
Masanori MURANAKA
Epizootic Research Center, Equine Research Institute, Japan Racing Association
Hiroshi BANNAI
Epizootic Research Center, Equine Research Institute, Japan Racing Association
Manabu NEMOTO
Epizootic Research Center, Equine Research Institute, Japan Racing Association
Takashi YAMANAKA
Epizootic Research Center, Equine Research Institute, Japan Racing Association
Takashi KONDO
Epizootic Research Center, Equine Research Institute, Japan Racing Association
Masakatsu KATO
Hokkaido Hidaka Livestock Hygiene Service Center
Tomio MATSUMURA
Epizootic Research Center, Equine Research Institute, Japan Racing Association

Keywords: EHV-1, neuropathogenic genotype, prevalence in Japan

JOURNAL FREE ACCESS

2011 Volume 73 Issue 12 Pages 1663-1667

DOI https://doi.org/10.1292/jvms.11-0140

View "Advance Publication" version (August 9, 2011).

Details

Abstract

A single non-synonymous nucleotide substitution of guanine (G) for adenine (A) at position 2254 in the viral DNA polymerase gene (encoded by open reading frame [ORF] 30) of equine herpesvirus type 1 (EHV-1) has been significantly associated with neuropathogenic potential in strains of this virus. To estimate the prevalence of EHV-1 strains with the neuropathogenic genotype (ORF30 G₂₂₅₄) in the Hidaka district-a major horse breeding area in Japan-we analyzed the ORF30 genomic region in cases of EHV-1 infection in this area during the years 2001-2010. Of the 113 cases analyzed, 3 (2.7%) were induced by ORF30 G₂₂₅₄ strains. This prevalence is lower than those observed in the U.S.A. (10.8-19.4%), Argentina (7.4%), France (24%), and Germany (10.6%).

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