Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Leprfa (SDT Fatty) Rats

Takayuki YAMAGUCHI; Tomohiko SASASE; Yasuko MERA; Daisuke TOMIMOTO; Hironobu TADAKI; Yusuke KEMMOCHI; Takeshi OHTA; Eimei SATO; Mutsuyoshi MATSUSHITA

doi:10.1292/jvms.12-0149

Laboratory Animal Science

Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Lepr^fa (SDT Fatty) Rats

Takayuki YAMAGUCHI, Tomohiko SASASE, Yasuko MERA, Daisuke TOMIMOTO, Hironobu TADAKI, Yusuke KEMMOCHI, Takeshi OHTA, Eimei SATO, Mutsuyoshi MATSUSHITA

著者情報

Takayuki YAMAGUCHI
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
Tomohiko SASASE
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
Yasuko MERA
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
Daisuke TOMIMOTO
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
Hironobu TADAKI
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
Yusuke KEMMOCHI
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 23 Naganuki, Hadano, Kanagawa 257–0024, Japan
Takeshi OHTA
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan
Eimei SATO
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Faculty of Agriculture, Tohoku University, 1–1 Amamiya-machi, Tsutsumi-dori, Aoba-ku, Sendai 981–8555, Japan
Mutsuyoshi MATSUSHITA
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1–1 Murasaki-cho, Takatsuki, Osaka 569–1125, Japan

キーワード: diabetes, diabetic peripheral neuropathy, nerve conduction velocity, SDT fatty rat

ジャーナルフリー

2012 年 74 巻 12 号 p. 1669-1673

DOI https://doi.org/10.1292/jvms.12-0149

Browse “Advance online publication” version

詳細

抄録

Spontaneously Diabetic Torii (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia is late. SDT fatty rat, established by introducing the fa allele of the Zucker fatty rat to SDT rat, develops diabetes much faster than SDT rat. In the present study, diabetic peripheral neuropathy (DPN) was evaluated to show the further usefulness of this animal model. Motor nerve conduction velocity (MNCV) was delayed, and the number of sural nerve fibers was decreased in SDT fatty rat. Treatment of pioglitazone lowered blood glucose level and prevented delay of MNCV in SDT fatty rats. SDT fatty rat is a useful animal model for studies of DPN in type 2 diabetes.

責任著者(Corresponding author)

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