Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in          the natural host, sheep

Tomokazu TAMURA; Junki MINE; Shiho TORII; Yuri FUJIMOTO; Masatoshi OKAMATSU; Yoshihiro SAKODA

doi:10.1292/jvms.14-0434

Virology

Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep

Tomokazu TAMURA, Junki MINE, Shiho TORII, Yuri FUJIMOTO, Masatoshi OKAMATSU, Yoshihiro SAKODA

著者情報

Tomokazu TAMURA
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060–0818, Japan
Junki MINE
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060–0818, Japan
Shiho TORII
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060–0818, Japan
Yuri FUJIMOTO
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060–0818, Japan
Masatoshi OKAMATSU
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060–0818, Japan
Yoshihiro SAKODA
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060–0818, Japan
Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo 001–0020, Japan

キーワード: border disease virus, host, pathogenicity, sheep

ジャーナルフリー

2015 年 77 巻 3 号 p. 341-343

DOI https://doi.org/10.1292/jvms.14-0434

Browse “Advance online publication” version

詳細

抄録

A first isolation of border disease virus (BDV) in Japan was from a pig on a farm without keeping any ruminants. Our previous study showed that this BDV, termed the FNK2012-1 strain, replicated inefficiently in swine-derived cells compared with those of ruminant origin. Pigs inoculated with this virus showed neither clinical symptoms nor viremia. In this study, we evaluated the pathogenicity of the FNK2012-1 strain in sheep, its natural host. The inoculated sheep showed clinical symptoms and transient viremia. Seroconversion was observed in the inoculated sheep. These results suggest that the FNK2012-1 strain was introduced from sheep and has not yet adapted to swine. Therefore, surveillance of border disease in Japan is necessary among both the swine and ruminant populations.

責任著者(Corresponding author)

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