Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog

Kosuke KOBAYASHI; Takako SHIMOKAWA MIYAMA; Kazuhito ITAMOTO; Shunsuke NOGUCHI; Kenji BABA; Takuya MIZUNO; Masaru OKUDA

doi:10.1292/jvms.16-0019

Internal Medicine

Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog

Kosuke KOBAYASHI, Takako SHIMOKAWA MIYAMA, Kazuhito ITAMOTO, Shunsuke NOGUCHI, Kenji BABA, Takuya MIZUNO, Masaru OKUDA

著者情報

Kosuke KOBAYASHI
Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1, Yoshida, Yamaguchi 753–8511, Japan
Takako SHIMOKAWA MIYAMA
Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1, Yoshida, Yamaguchi 753–8511, Japan
Kazuhito ITAMOTO
Animal Medical Center, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1, Yoshida, Yamaguchi 753–8511, Japan
Shunsuke NOGUCHI
Laboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1, Yoshida, Yamaguchi 753–8511, Japan
Kenji BABA
Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1, Yoshida, Yamaguchi 753–8511, Japan
Takuya MIZUNO
Laboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1, Yoshida, Yamaguchi 753–8511, Japan
Masaru OKUDA
Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1, Yoshida, Yamaguchi 753–8511, Japan

キーワード: danazol, hepatocellular carcinoma, immune-mediated anemia, immunosuppressive therapy

ジャーナルフリー

2016 年 78 巻 10 号 p. 1611-1614

DOI https://doi.org/10.1292/jvms.16-0019

Browse “Advance online publication” version

詳細

抄録

A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol was successful in treating the anemia. However, hepatocellular carcinoma (HCC) developed about 20 months after the administration of danazol. In humans, several cases of development of HCC after the administration of danazol have been reported. The present report describes a case of HCC development in a dog after chronic administration of danazol in addition to other immunosuppressive drugs.

責任著者(Corresponding author)

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