Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog

Kosuke KOBAYASHI; Takako SHIMOKAWA MIYAMA; Kazuhito ITAMOTO; Shunsuke NOGUCHI; Kenji BABA; Takuya MIZUNO; Masaru OKUDA

doi:10.1292/jvms.16-0019

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Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog

Kosuke KOBAYASHI, Takako SHIMOKAWA MIYAMA, Kazuhito ITAMOTO, Shunsuke NOGUCHI, Kenji BABA, Takuya MIZUNO, Masaru OKUDA

著者情報

キーワード: danazol, hepatocellular carcinoma, immune-mediated anemia, immunosuppressive therapy

ジャーナルフリー早期公開

論文ID: 16-0019

DOI https://doi.org/10.1292/jvms.16-0019

この記事には本公開記事があります。

The final version of this article is now available: Vol. 78 (2016), No. 10 pp. 1611-1614

詳細

抄録

A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol was successful in treating the anemia. However, hepatocellular carcinoma (HCC) developed about 20 months after the administration of danazol. In humans, several cases of development of HCC after the administration of danazol have been reported. The present report describes a case of HCC development in a dog after chronic administration of danazol in addition to other immunosuppressive drugs.

責任著者(Corresponding author)

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