Intrauterine infection with bovine leukemia virus in pregnant dam with high          viral load

Yamato SAJIKI; Satoru KONNAI; Asami NISHIMORI; Tomohiro OKAGAWA; Naoya MAEKAWA; Shinya GOTO; Masashi NAGANO; Junko KOHARA; Nana KITANO; Toshihiko TAKAHASHI; Motoshi TAJIMA; Hirohisa MEKATA; Yoichiro HORII; Shiro MURATA; Kazuhiko OHASHI

doi:10.1292/jvms.17-0391

Virology

Intrauterine infection with bovine leukemia virus in pregnant dam with high viral load

Yamato SAJIKI, Satoru KONNAI, Asami NISHIMORI, Tomohiro OKAGAWA, Naoya MAEKAWA, Shinya GOTO, Masashi NAGANO, Junko KOHARA, Nana KITANO, Toshihiko TAKAHASHI, Motoshi TAJIMA, Hirohisa MEKATA, Yoichiro HORII, Shiro MURATA, Kazuhiko OHASHI

著者情報

Yamato SAJIKI
Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
Satoru KONNAI
Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
Asami NISHIMORI
Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
Tomohiro OKAGAWA
Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
Naoya MAEKAWA
Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
Shinya GOTO
Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
Masashi NAGANO
Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
Junko KOHARA
Animal Research Center, Agricultural Research Department, Hokkaido Research Organization, Shintoku, Hokkaido 081-0038, Japan
Nana KITANO
Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan
Toshihiko TAKAHASHI
Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan
Motoshi TAJIMA
Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan
Hirohisa MEKATA
Organization for Promotion of Tenure Track, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan
Center for Animal Disease Control, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan
Yoichiro HORII
Center for Animal Disease Control, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan
Shiro MURATA
Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
Kazuhiko OHASHI
Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan

キーワード: bovine leukemia virus, high proviral load, intrauterine infection, vertical transmission

ジャーナルフリー

2017 年 79 巻 12 号 p. 2036-2039

DOI https://doi.org/10.1292/jvms.17-0391

Browse “Advance online publication” version

詳細

抄録

Enzootic bovine leukemia is caused by the bovine leukemia virus (BLV). BLV is transmitted vertically or horizontally through the transfer of infected cells via direct contact, through milk, insect bites and contaminated iatrogenic procedures. However, we lacked direct evidence of intrauterine infection. The purpose of this study was to confirm intrauterine BLV infection in two pregnant dams with high viral load by cesarean delivery. BLV was detected in cord and placental blood, and the BLV in the newborns showed 100% nucleotide identity with the BLV-env sequence from the dams. Notably, a newborn was seropositive for BLV but had no colostral antibodies. In this study, we presented a direct evidence of intrauterine BLV transmission in pregnant dam with a high proviral load. These results could aid the development of BLV control measures targeting viral load.

責任著者(Corresponding author)

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