Virucidal activity of a quaternary ammonium compound associated with calcium          hydroxide on avian influenza virus, Newcastle disease virus and infectious bursal disease          virus

Mariko ITO; Md. Shahin ALAM; Mayuko SUZUKI; Satoru TAKAHASHI; Miyuki KOMURA; Natthanan SANGSRIRATAKUL; Dany SHOHAM; Kazuaki TAKEHARA

doi:10.1292/jvms.18-0006

Avian Pathology

Virucidal activity of a quaternary ammonium compound associated with calcium hydroxide on avian influenza virus, Newcastle disease virus and infectious bursal disease virus

Mariko ITO, Md. Shahin ALAM, Mayuko SUZUKI, Satoru TAKAHASHI, Miyuki KOMURA, Natthanan SANGSRIRATAKUL, Dany SHOHAM, Kazuaki TAKEHARA

Author information

Mariko ITO
Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan
Md. Shahin ALAM
Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan
The United Graduate School of Veterinary Science, Gifu University, 1-1, Yanagido, Gifu 501-1193, Japan
Mayuko SUZUKI
Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan
Satoru TAKAHASHI
Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan
Miyuki KOMURA
Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan
Natthanan SANGSRIRATAKUL
Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan
The United Graduate School of Veterinary Science, Gifu University, 1-1, Yanagido, Gifu 501-1193, Japan
Dany SHOHAM
Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan
Bar-Ilan University, Begin-Sadat Center for Strategic Studies, Ramat Gan 5290002, Israel
Kazuaki TAKEHARA
Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan
The United Graduate School of Veterinary Science, Gifu University, 1-1, Yanagido, Gifu 501-1193, Japan

Keywords: food additive grade calcium hydroxide (FdCa(OH)₂), poultry viral pathogens, quaternary ammonium compound, synergistic effects, virucide

JOURNAL FREE ACCESS

2018 Volume 80 Issue 4 Pages 574-577

DOI https://doi.org/10.1292/jvms.18-0006

Browse “Advance online publication” version

Details

Abstract

A quaternary ammonium compound (QAC) was evaluated for its virucidal efficacies with food additive grade calcium hydroxide (FdCa(OH)₂). When the QAC was diluted 1:500 (QACx500) with redistilled water (dW₂), it inactivated avian influenza virus (AIV) within 30 sec at 25°C, while at 2°C, it required 1 hr for inactivation. When FdCa(OH)₂ powder was added to QACx500 at a final concentration of 0.17%, the mixture, namely Mix500, inactivated AIV within 3 min at 2°C. After contamination with 1% fetal bovine serum (FBS), Mix500 inactivated AIV within 2 hr at 2°C, but QACx500 did not. These results indicate synergistic effects of the QAC and FdCa(OH)₂ solutions on virucidal activity.

Corresponding author

Register with J-STAGE for free!