Effect of medetomidine on tear flow measured by Schirmer tear test I in          normal pigs

Teppei KANDA; Ayumu KAJIYAMA; Waka MORIMITSU; Yukiko NISHINO; Yutaro OISHI; Yuki SHIMIZU; Noritaka MAETA; Kayo FURUMOTO; Yoshiki ITOH; Toshinori FURUKAWA

doi:10.1292/jvms.18-0660

Surgery

Effect of medetomidine on tear flow measured by Schirmer tear test I in normal pigs

Teppei KANDA, Ayumu KAJIYAMA, Waka MORIMITSU, Yukiko NISHINO, Yutaro OISHI, Yuki SHIMIZU, Noritaka MAETA, Kayo FURUMOTO, Yoshiki ITOH, Toshinori FURUKAWA

Author information

Teppei KANDA
Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoinooka, Imabari, Ehime 794-8555, Japan
Department of Comparative Animal Science, College of Life Science, Kurashiki University of Science and the Arts, 2640 Nishinoura, Tsurajima-cho, Kurashiki, Okayama 712-8505, Japan
Ayumu KAJIYAMA
Department of Comparative Animal Science, College of Life Science, Kurashiki University of Science and the Arts, 2640 Nishinoura, Tsurajima-cho, Kurashiki, Okayama 712-8505, Japan
Waka MORIMITSU
Department of Comparative Animal Science, College of Life Science, Kurashiki University of Science and the Arts, 2640 Nishinoura, Tsurajima-cho, Kurashiki, Okayama 712-8505, Japan
Yukiko NISHINO
Department of Comparative Animal Science, College of Life Science, Kurashiki University of Science and the Arts, 2640 Nishinoura, Tsurajima-cho, Kurashiki, Okayama 712-8505, Japan
Yutaro OISHI
Department of Comparative Animal Science, College of Life Science, Kurashiki University of Science and the Arts, 2640 Nishinoura, Tsurajima-cho, Kurashiki, Okayama 712-8505, Japan
Yuki SHIMIZU
Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoinooka, Imabari, Ehime 794-8555, Japan
Department of Comparative Animal Science, College of Life Science, Kurashiki University of Science and the Arts, 2640 Nishinoura, Tsurajima-cho, Kurashiki, Okayama 712-8505, Japan
Noritaka MAETA
Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoinooka, Imabari, Ehime 794-8555, Japan
Kayo FURUMOTO
Department of Comparative Animal Science, College of Life Science, Kurashiki University of Science and the Arts, 2640 Nishinoura, Tsurajima-cho, Kurashiki, Okayama 712-8505, Japan
Yoshiki ITOH
Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoinooka, Imabari, Ehime 794-8555, Japan
Toshinori FURUKAWA
Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoinooka, Imabari, Ehime 794-8555, Japan

Keywords: α₂-adrenoceptor, medetomidine, pig, Schirmer tear test, tear

JOURNAL FREE ACCESS

2019 Volume 81 Issue 4 Pages 538-540

DOI https://doi.org/10.1292/jvms.18-0660

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Abstract

Medetomidine, an α₂-adrenoceptor agonist, was reported to decrease tear flow in some species. However, there are no reports about the effect of medetomidine on tear flow in pigs. The purpose of this study was to elucidate it. The study was performed in 10 clinically normal female Landrace pigs aged 3 months. Tear flow was measured by the Schirmer tear test (STT) I before (baseline) and 15 and 30 min after intramuscular administration of 80 µg/kg medetomidine. Compared to the STT I value at baseline, the value decreased significantly at 30 min after administration in both the left and right eyes. In pigs treated with medetomidine, an artificial tear solution or ophthalmic gel should be applied to protect the ocular surface.

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