Comparing the Effects of Acupuncture and Electroacupuncture at Zusanli and Baihui on Cell Proliferation and Neuroblast Differentiation in the Rat Hippocampus

In Koo HWANG; Jin Young CHUNG; Dae Young YOO; Sun Shin YI; Hwa Young YOUN; Je Kyung SEONG; Yeo Sung YOON

doi:10.1292/jvms.09-0374

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Comparing the Effects of Acupuncture and Electroacupuncture at Zusanli and Baihui on Cell Proliferation and Neuroblast Differentiation in the Rat Hippocampus

In Koo HWANG, Jin Young CHUNG, Dae Young YOO, Sun Shin YI, Hwa Young YOUN, Je Kyung SEONG, Yeo Sung YOON

著者情報

キーワード: acupuncture, electroacupuncture, cell proliferation, neuroblast differentiation, Wistar rats

ジャーナルフリー早期公開

論文ID: 09-0374

DOI https://doi.org/10.1292/jvms.09-0374

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2010) , No. 3 p.279

詳細

抄録

We compared the effects of acupuncture and electroacupuncture on cell proliferation and neuroblast differentiation using specific markers, Ki67 and doublecortin (DCX), in the subgranular zone of the dentate gyrus (SZDG) in 13-week old Wistar rats. Acupuncture and electroacupuncture were applied simultaneously in the acu-points, ST36 (Zusanli) and GV20 (Baihui), once a day for 3 weeks. Acupuncture and electroacupuncture at these acu-points significantly increased the number of Ki67-positive cells and DCX-immunoreactive neuroblasts compared to the control or sham acupuncture group. Electroacupuncture treatment significantly increased the number of well-developed (tertiary) dendrites in the SZDG compared to acupuncture treatment. These results suggest that both acupuncture and electroacupuncture increase neurogenesis in the normal, but that electroacupuncture has greater effects on neuroblast plasticity than acupuncture in the dentate gyrus.

責任著者(Corresponding author)

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