Function of Feline Signaling Lymphocyte Activation Molecule as a Receptor of Canine Distemper Virus

Yuka HARA; Junko SUZUKI; Keita NOGUCHI; Yutaka TERADA; Hiroshi SHIMODA; Takuya MIZUNO; Ken MAEDA

doi:10.1292/jvms.13-0003

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Function of Feline Signaling Lymphocyte Activation Molecule as a Receptor of Canine Distemper Virus

Yuka HARA, Junko SUZUKI, Keita NOGUCHI, Yutaka TERADA, Hiroshi SHIMODA, Takuya MIZUNO, Ken MAEDA

著者情報

キーワード: canine distemper virus, feline, signaling lymphocyte activation molecul

ジャーナルフリー早期公開

論文ID: 13-0003

DOI https://doi.org/10.1292/jvms.13-0003

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2013), No. 8 pp. 1085-1089

詳細

抄録

Morbilliviruses use signaling lymphocyte activation molecule (SLAM) as a receptor for their entry to cells. In this study, a complete gene encoding SLAM of a domestic cat was identified. The identity of feline SLAM with canine one was 73%, and feline SLAM formed the same cluster with those of carnivores. Furthermore, feline cell expressing feline SLAM supported growth of canine distemper virus (CDV) as well as that expressing canine one. These results indicated that feline SLAM can function as a receptor for morbilliviruses, and our established feline cells that express feline SLAM might be useful for analysis of morbilliviruses originated from felids.

責任著者(Corresponding author)

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