Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
Profiling of plasma metabolites in canine oral melanoma using gas chromatography-mass spectrometry
Mifumi KAWABEYuta BABAReo TAMAIRyohei YAMAMOTOMasayuki KOMORITakashi MORIShigeo TAKENAKA
著者情報
ジャーナル フリー 早期公開

論文ID: 14-0641

詳細
抄録

Malignant melanoma is one of the most common and aggressive tumors in the oral cavity of dog. The tumor has a poor prognosis, and methods for diagnosis and prediction of prognosis after treatment are required. Here, we examined metabolite profiling using gas chromatography-mass spectrometry (GC-MS) for development of a discriminant model for evaluation of prognosis. Metabolite profiles were evaluated in healthy and melanoma plasma samples using orthogonal projection to latent structure using discriminant analysis (OPLS-DA). Cases that were predicted to be healthy using the OPLS discriminant model had no advanced lesions after radiation therapy. These results indicate that metabolite profiling may be useful in diagnosis and prediction of prognosis of canine malignant melanoma.

著者関連情報
feedback
Top