Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats

Kazutaka KANAI; Sho NAGATA; Takuya HATTA; Youichi SUGIURA; Kazuaki SATO; Yohei YAMASHITA; Yuya KIMURA; Naoyuki ITOH

doi:10.1292/jvms.16-0196

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Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats

Kazutaka KANAI, Sho NAGATA, Takuya HATTA, Youichi SUGIURA, Kazuaki SATO, Yohei YAMASHITA, Yuya KIMURA, Naoyuki ITOH

著者情報

キーワード: anti-inflammatory effect, endotoxin-induced uveitis, luteolin, prednisolone, therapeutic effect

ジャーナルフリー早期公開

論文ID: 16-0196

DOI https://doi.org/10.1292/jvms.16-0196

この記事には本公開記事があります。

The final version of this article is now available: Vol. 78 (2016), No. 8 pp. 1381-1384

詳細

抄録

The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4hr post-lipopolysaccharide (LPS) injection (200 µg) was associated at 24 hr post-LPS injection with decreased clinical severity scores, number of inflammatory cells, protein levels and levels of tumor necrosis factor (TNF)-α, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH) and degrees of histological ocular tissue injury. The anti-inflammatory potency of luteolin was comparable to that of Pred. Luteolin exhibited robust efficacy in the treatment of EIU in rats, indicating its potential clinical utility in treating uveitis.

責任著者(Corresponding author)

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