Plasma Concentrations of Substances Suspected as Uremic Toxins in Experimentally Induced and Spontaneous Uremic Dogs

Abstract

Plasma concentrations of four substances, a pyridine derivative (S7_a), uric acid (UA), hippuric acid (HA) and kynurenic acid (KA), suspected as uremic toxins in dogs were determined in dogs with experimentally induced uremia by the ligations of renal arteries, spontaneous uremic dog patients and normal dogs. In experimentally induced uremic dogs, plasma concentrations of S7_a, HA and KA showed continuous increase after the ligation of renal arteries together with a significant correlation to plasma creatinine concentration (Crc). Plasma UA concentration increased rapidly, but it showed a varying fluctuation without showing any correlation to Crc. Plasma concentrations of S7_a, UA, HA and KA in spontaneous uremic dogs were almost within the ranges of those of experimentally induced uremic dogs.